Positive and negative regulation of endogenous genes by designed transcription factors
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چکیده
منابع مشابه
Positive and negative regulation of endogenous genes by designed transcription factors.
Gene regulation by imposed localization was studied by using designed zinc finger proteins that bind 18-bp DNA sequences in the 5' untranslated regions of the protooncogenes erbB-2 and erbB-3. Transcription factors were generated by fusion of the DNA-binding proteins to repression or activation domains. When introduced into cells these transcription factors acted as dominant repressors or activ...
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Acute promyelocytic leukemia (APL) is always associated with chromosomal translocations that disrupt the retinoic acid receptor a (RARa) gene. Whether these translocations relate to a role for endogenous RARa in normal granulopoiesis remains uncertain because most studies addressing this question have used nonphysiological overexpression systems. Granulocyte differentiation in cells derived fro...
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Acute promyelocytic leukemia (APL) is always associated with chromosomal translocations that disrupt the retinoic acid receptor alpha (RARalpha) gene. Whether these translocations relate to a role for endogenous RARalpha in normal granulopoiesis remains uncertain because most studies addressing this question have used non-physiological overexpression systems. Granulocyte differentiation in cell...
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Introduction The protein hormone insulin plays a decisive role in the control of mammalian glucose homeostasis. In adults, production of insulin is stringently restricted to the B cells of the endocrine pancreas. The major mechanism directing this specificity operates at the transcriptional level; as a result, insulin mRNA levels are extremely low in n0n-B cells, of the order of 10' lower than ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.040552697